Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
USERS' SCORE
Good
Based on 7 Reviews
8
Supplement Facts
Serving Size: 1 Fish Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Cholesterol
<5 mg
1%
Vitamin D3 (as Cholecalciferol) (from Lanolin)
25 mcg (1,000 IU)
125%
Fish Oil Concentrate
1.2 g (1,200 mg)
†
Omega-3 Fatty Acids:
Eicosapentaenoic Acid (EPA)
600 mg
†
Docosahexaenoic Acid (DHA)
300 mg
†
Top Medical Research Studies
7
We examined the effects of omega-3 supplementation on rheumatoid arthritis through a meta-analysis of 18 randomized controlled trials involving over 1,000 patients.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
Our findings showed that omega-3 increased beneficial fatty acids and decreased triglyceride levels and tender joint counts.
However, while there were some reductions in inflammation markers, these changes weren't statistically significant, suggesting that omega-3 might not drastically alter disease activity overall.
Read More
We conducted a systematic review of randomized placebo-controlled trials to investigate whether omega-3 fatty acids can benefit those with rheumatoid arthritis (RA). Our analysis of 23 studies found that while there were some signs of reduced pain and fewer tender and swollen joints, the effects were minimal and not clinically significant.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Read More
8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
Read More
Most Useful Reviews
9
Effective for arthritis
It has been shown that fish oil prevents osteoporosis. The EPA and DHA in fish oil stop processes that lead to bone loss and lessen inflammation. Daily Omega-3 PUFA consumption alleviates joint pain. Additionally, fish oil is an essential source of vitamin D for osteoporosis treatment. Regular intake of high concentrations of omega-3s can significantly decrease inflammatory processes in rheumatoid arthritis and relieve pain and morning stiffness, at times completely. Furthermore, omega-3 fatty acids can lessen the need for non-steroidal anti-inflammatory drugs, which often cause gastrointestinal issues.
Read More
9
Good value for RA
Excellent for RA! This omega-3 supplement greatly benefits my rheumatoid arthritis when taken consistently. It's good value for the price, offering high quality at a lower cost compared to other brands. I've noticed it helps to reduce inflammation.
Read More
7.5
Pain relief noted
Excellent! Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during flare-ups. These fatty acids combat bone loss and inflammation, help reduce the symptoms of rheumatoid arthritis, and slow the degradation of articular cartilage in arthrosis.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.6
- All Researches
8
We examined the effects of omega-3 fatty acids on autoimmune diseases through a comprehensive review and a Mendelian randomization analysis. Our findings suggest that omega-3 fatty acids can help reduce disease activity and lower inflammation in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
However, while the evidence is promising for RA, there was no consistent proof of omega-3s aiding other autoimmune conditions. Overall, further research is needed to build on our understanding of omega-3 fatty acids across various autoimmune diseases.
Read More
8
Promising therapy for rheumatoid arthritis
We explored the impact of a lipid mediator derived from docosahexaenoic acid (DHA) on rheumatoid arthritis. In our study, the mediator showed promise in reducing inflammation in mice with collagen antibody-induced arthritis.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
This treatment significantly decreased joint swelling and improved overall arthritis symptoms. Additionally, it lowered levels of harmful cytokines in the serum and boosted protective cytokines.
Our findings suggest that this lipid mediator could be a beneficial addition to rheumatoid arthritis therapy, potentially alleviating symptoms and repairing joint damage.
Read More
8
This study focused on how omega-3 and omega-6 fatty acids might influence disease activity in patients with early rheumatoid arthritis (RA). We examined the serum profiles of 669 patients and identified distinct fatty acid patterns.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
Our findings revealed that a higher presence of omega-3 fatty acids was linked to lower disease activity after six months. Similarly, an omega-6 profile also showed reduced disease activity. These results suggest that incorporating these fatty acids could beneficially impact RA management.
Read More
8
We examined the potential benefits of omega-3 fatty acids on rheumatoid arthritis (RA) through a systematic review of 71 studies. Our findings suggest that a diet rich in these fatty acids may help reduce pain and disease activity in RA patients.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Read More
8
We explored the impact of omega-3 fatty acids on pain relief in rheumatoid arthritis (RA) patients treated with Janus kinase inhibitors (JAKi).
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
By analyzing lipid levels, we found that those on JAKi showed a significant increase in omega-3 fatty acids and docosahexaenoic acid (DHA).
Notably, 66.7% of these patients reported manageable pain after 24 weeks, and the reduction in pain correlated with the rise in DHA levels. This suggests that omega-3 fatty acids may play a key role in enhancing the pain-relief benefits of JAKi treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for arthritis
It has been shown that fish oil prevents osteoporosis. The EPA and DHA in fish oil stop processes that lead to bone loss and lessen inflammation. Daily Omega-3 PUFA consumption alleviates joint pain. Additionally, fish oil is an essential source of vitamin D for osteoporosis treatment. Regular intake of high concentrations of omega-3s can significantly decrease inflammatory processes in rheumatoid arthritis and relieve pain and morning stiffness, at times completely. Furthermore, omega-3 fatty acids can lessen the need for non-steroidal anti-inflammatory drugs, which often cause gastrointestinal issues.
Read More
9
Good value for RA
Excellent for RA! This omega-3 supplement greatly benefits my rheumatoid arthritis when taken consistently. It's good value for the price, offering high quality at a lower cost compared to other brands. I've noticed it helps to reduce inflammation.
Read More
7.5
Pain relief noted
Excellent! Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during flare-ups. These fatty acids combat bone loss and inflammation, help reduce the symptoms of rheumatoid arthritis, and slow the degradation of articular cartilage in arthrosis.
Read More
7.5
Inflammation reduction
Omega-3 fatty acids prevent osteoporosis, keep joints healthy, and alleviate pain during flare-ups. They combat bone loss and inflammation while helping to reduce the symptoms of rheumatoid arthritis, thereby slowing the erosion of articular cartilage in arthrosis.
Read More
7.5
Joint health support
Omega-3s promote joint health, prevent osteoporosis, and reduce inflammation, aiding in bone preservation. They ease joint pain and alleviate symptoms of rheumatoid arthritis while decelerating the deterioration of articular cartilage in arthrosis. I take one capsule daily with my family and find it beneficial.
Read More
Frequently Asked Questions
9
Good value for RA
Excellent for RA! This omega-3 supplement greatly benefits my rheumatoid arthritis when taken consistently. It's good value for the price, offering high quality at a lower cost compared to other brands. I've noticed it helps to reduce inflammation.
7.5
Joint health support
Omega-3s promote joint health, prevent osteoporosis, and reduce inflammation, aiding in bone preservation. They ease joint pain and alleviate symptoms of rheumatoid arthritis while decelerating the deterioration of articular cartilage in arthrosis. I take one capsule daily with my family and find it beneficial.
6
Modest pain reduction
Fish oil is a source of omega-3 fatty acids, which your body requires for various functions. Omega-3 fatty acids cannot be manufactured internally and must be obtained from food, particularly fatty fish and some nuts. Some studies indicate that fish oil supplements may assist in diminishing pain, improving morning stiffness, and relieving joint tenderness associated with rheumatoid arthritis, although the relief experienced is often modest.
4
Supports health overall
Cheap and effective, fish oil is high in eicosapentaenoic acid (EPA), an Omega-3 fatty acid. EPA plays a key role in heart health, reducing triglyceride and cholesterol levels. Its anti-inflammatory effects can alleviate symptoms of chronic inflammation, including rheumatoid arthritis. It also promotes brain function and mood regulation. The correct dosage is essential, and consulting a healthcare professional is recommended for individual guidance.
9
Effective for arthritis
It has been shown that fish oil prevents osteoporosis. The EPA and DHA in fish oil stop processes that lead to bone loss and lessen inflammation. Daily Omega-3 PUFA consumption alleviates joint pain. Additionally, fish oil is an essential source of vitamin D for osteoporosis treatment. Regular intake of high concentrations of omega-3s can significantly decrease inflammatory processes in rheumatoid arthritis and relieve pain and morning stiffness, at times completely. Furthermore, omega-3 fatty acids can lessen the need for non-steroidal anti-inflammatory drugs, which often cause gastrointestinal issues.
7
Omega-3 improves rheumatoid arthritis symptoms
We examined how oral supplementation with polyunsaturated fatty acids (PUFAs), particularly omega-3 from animal sources, affects rheumatoid arthritis (RA) symptoms.
The study involved 30 randomized controlled trials with 1,420 participants, revealing that patients taking over 2 grams of omega-3 daily experienced improvements in pain, joint swelling, and overall disease activity.
While omega-3 showed more significant benefits compared to vegetable sources, it’s essential to note that not all inflammatory rheumatic diseases responded the same way.
The study involved 30 randomized controlled trials with 1,420 participants, revealing that patients taking over 2 grams of omega-3 daily experienced improvements in pain, joint swelling, and overall disease activity.
While omega-3 showed more significant benefits compared to vegetable sources, it’s essential to note that not all inflammatory rheumatic diseases responded the same way.
We conducted a systematic review of randomized placebo-controlled trials to investigate whether omega-3 fatty acids can benefit those with rheumatoid arthritis (RA). Our analysis of 23 studies found that while there were some signs of reduced pain and fewer tender and swollen joints, the effects were minimal and not clinically significant.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
Additionally, we noted a small reduction in the intake of NSAIDs and c-reactive protein levels, but overall, the evidence quality was low. Thus, omega-3 supplementation appears to have limited effectiveness in managing RA symptoms.
8
We examined the potential benefits of omega-3 fatty acids on rheumatoid arthritis (RA) through a systematic review of 71 studies. Our findings suggest that a diet rich in these fatty acids may help reduce pain and disease activity in RA patients.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
Consuming fish, a primary source of omega-3s, could also lower the incidence of RA. Given their anti-inflammatory properties, we believe that integrating omega-3s into treatment plans, alongside standard medications, could significantly enhance the quality of life for those living with RA.
References
- Wang Y, Hu S, Zhang W, Zhang B, Yang Z. Dietary factors and rheumatoid arthritis: new perspectives from a Mendelian randomisation analysis. Br J Nutr. 2025;133:107. 10.1017/S0007114524002721
- Hong K, Hun M, Wu F, Mao J, Wang Y, et al. Association between Omega-3 fatty acids and autoimmune disease: Evidence from the umbrella review and Mendelian randomization analysis. Autoimmun Rev. 2024;23:103651. 10.1016/j.autrev.2024.103651
- Wang W, Xu Y, Zhou J, Zang Y. Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Clin Rheumatol. 2024;43:2479. 10.1007/s10067-024-07040-0
- Kang T, Xi Y, Qian T, Lu S, Du M, et al. Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. 2024;42:1720. 10.55563/clinexprheumatol/91tmfb
- Laevski AM, Doucet MR, Doucet MS, LeBlanc AA, Pineau PE, et al. Dietary omega-3 fatty acids modulate the production of platelet-derived microvesicles in an in vivo inflammatory arthritis model. Eur J Nutr. 2024;63:2221. 10.1007/s00394-024-03397-9
- Su Y, Han Y, Choi HS, Lee GY, Cho HW, et al. Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis. Biomed Pharmacother. 2024;171:116153. 10.1016/j.biopha.2024.116153
- Léger T, Brun A, Lanchais K, Rigaudière JP, Briat A, et al. Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect. Life Sci. 2023;327:121826. 10.1016/j.lfs.2023.121826
- Marchand NE, Choi MY, Oakes EG, Cook NR, Stevens E, et al. Over-the-counter fish oil supplementation and pro-resolving and pro-inflammatory lipid mediators in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2023;190:102542. 10.1016/j.plefa.2023.102542
- Gkiouras K, Grammatikopoulou MG, Myrogiannis I, Papamitsou T, Rigopoulou EI, et al. Efficacy of n-3 fatty acid supplementation on rheumatoid arthritis' disease activity indicators: a systematic review and meta-analysis of randomized placebo-controlled trials. Crit Rev Food Sci Nutr. 2024;64:16. 10.1080/10408398.2022.2104210
- Sigaux J, Bellicha A, Buscail C, Julia C, Flipo RM, et al. Serum Fatty Acid Profiles Are Associated with Disease Activity in Early Rheumatoid Arthritis: Results from the ESPOIR Cohort. Nutrients. 2022;14. 10.3390/nu14142947
- Sigaux J, Mathieu S, Nguyen Y, Sanchez P, Letarouilly JG, et al. Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis. Arthritis Res Ther. 2022;24:100. 10.1186/s13075-022-02781-2
- Tański W, Świątoniowska-Lonc N, Tabin M, Jankowska-Polańska B. The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis. Nutrients. 2022;14. 10.3390/nu14051030
- Amjad S, Ahmad N, Afreen A, Ashraf S, Ahmed Z. Efficacy of Flaxseed and Fish Oils on Adults with Rheumatoid Arthritis. J Pak Med Assoc. 2022;72:22. 10.47391/JPMA.02-290
- Hahn J, Cook NR, Alexander EK, Friedman S, Walter J, et al. Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial. BMJ. 2022;376:e066452. 10.1136/bmj-2021-066452
- Chang CK, Chen PK, Chen CC, Chang SH, Chen CH, et al. Increased Levels of Omega-3 Fatty Acids and DHA Are Linked to Pain Reduction in Rheumatoid Arthritis Patients Treated with Janus Kinase Inhibitors. Nutrients. 2021;13. 10.3390/nu13093050
- Kucharská J, Poništ S, Vančová O, Gvozdjáková A, Uličná O, et al. Treatment with coenzyme Q10, omega-3-polyunsaturated fatty acids and their combination improved bioenergetics and levels of coenzyme Q9 and Q10 in skeletal muscle mitochondria in experimental model of arthritis. Physiol Res. 2021;70:723.
